Paul never forgot the responsibility resting on him as a minister of Christ, or that if souls were lost through unfaithfulness on his part, God would hold him accountable. "Whereof I am made a minister," he declared of the gospel, "according to the dispensation of God which is given to me for you, to fulfill the word of God; even the mystery which hath been hid from ages and from generations, but now is made manifest to His saints: to whom God would make known what is the riches of the glory of this mystery among the Gentiles; which is Christ in you, the hope of glory: whom we preach, warning every man, and teaching every man in all wisdom; that we may present every man perfect in Christ Jesus: whereunto I also labor, striving according to His working, which worketh in me mightily." Colossians 1:25-29.

Paulus glemte aldrig det ansvar, der påhvilede ham som Kristi tjener; heller ikke, at dersom sjæle gik fortabt ved forsømmelighed fra hans side, ville Gud gøre ham ansvarlig for dem. "Thi dens tjener er jeg blevet ifølge den husholdergerning fra Gud, som blev mig givet," siger han om menigheden, "at jeg overalt skal forkynde jer Guds ord, den hemmelighed, der har været skjult gennem alle tider og slægter, men nu er blevet åbenbaret for hans hellige; for dem ville Gud kundgøre, hvilken rigdom på herlighed denne hemmelighed rummer blandt hedningerne, nemlig Kristus i jer, herlighedens håb. Ham forkynder vi, idet vi påminder ethvert menneske og lærer ethvert menneske med al visdom, for at vi kan fremstille ethvert menneske som fuldkomment i Kristus. Det er også det, jeg arbejder og kæmper for med hans kraft, som virker mægtigt i mig." Kol. 1,25-29.