After describing the scenes of the trial already past, the desertion of his brethren, and the sustaining grace of a covenant-keeping God, and sending greeting to faithful fellow-laborers, Paul closes by commending his beloved Timothy to the guardianship of the Chief Shepherd, who, though the under-shepherds might be stricken down, would still care for his servants and his flock. {LP 327.2}

Efter at have beskrevet de trængsler der allerede var sket, sine brødres svigt, og en pagtopfyldende Guds understøttende nåde, og sendt hilsener til trofaste medarbejder, afslutter Paulus med at anbefale sin elskede Timotius til Hovedhyrdens formynderskab, som, selvom underhyrderne kan være nedslåede, stadig vil sørge for sine tjenere og hans hjord.